Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges

Autor/inn/en	Domingue, Benjamin W.; Trejo, Sam; Armstrong-Carter, Emma; Tucker-Drob, Elliot M.
Titel	Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges
Quelle	7 (2020), S.465-486 (22 Seiten)Infoseite zur Zeitschrift PDF als Volltext (1); PDF als Volltext kostenfreie Datei (2) Verfügbarkeit
Zusatzinformation	Weitere Informationen
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
DOI	10.15195/v7.a19
Schlagwörter	Genetics; Environmental Influences; Scores; Interaction; Scientific Research; Measurement; Error of Measurement; Research Methodology; Models + Suchen Sie Ihr Suchwort? Humangenetik; Environmental influence; Umwelteinfluss; Interaktion; Messverfahren; Messfehler; Research method; Forschungsmethode; Analogiemodell
Abstract	Interest in the study of gene-environment interaction has recently grown due to the sudden availability of molecular genetic data--in particular, polygenic scores--in many long-running longitudinal studies. Identifying and estimating statistical interactions comes with several analytic and inferential challenges; these challenges are heightened when used to integrate observational genomic and social science data. We articulate some of these key challenges, provide new perspectives on the study of gene-environment interactions, and end by offering some practical guidance for conducting research in this area. Given the sudden availability of well-powered polygenic scores, we anticipate a substantial increase in research testing for interaction between such scores and environments. The issues we discuss, if not properly addressed, may impact the enduring scientific value of gene-environment interaction studies. (As Provided).
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01